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Effects of domperidone on QTc interval in infants

M C Vieira1, N I Miyague, K Van Steen

  • 1Pediatric Gastroenterology, Hospital Pequeno Príncipe - Pontifical University of Paraná (PUCPR), Curitiba, Brazil.

Acta Paediatrica (Oslo, Norway : 1992)
|January 10, 2012
PubMed

Insights

Oral domperidone did not significantly alter QTc interval in infants with gastro-oesophageal reflux. However, a small percentage experienced QTc prolongation, suggesting routine monitoring is advisable.

Area of Science:

  • Pediatric Cardiology
  • Clinical Pharmacology

Background:

  • Gastro-oesophageal reflux (GOR) is common in infants.
  • Domperidone is frequently prescribed for GOR.
  • Potential QTc interval prolongation is a concern with domperidone.

Purpose of the Study:

  • To prospectively evaluate the effects of oral domperidone on the QTc interval in infants.
  • Assess domperidone's impact on cardiac repolarization in pediatric patients.

Main Methods:

  • Prospective study of infants (0-1 year) with GOR.
  • Electrocardiography (ECG) performed at baseline and 1 hour post-domperidone.
  • Corrected QTc interval calculated using Bazett's formula.

Main Results:

  • No statistically significant difference in QTc interval observed overall.
  • A trend towards QTc prolongation was noted in male infants (p=0.051).
  • Two infants (4.4%) showed clinically significant QTc prolongation (>460 msec).

Conclusions:

  • Domperidone did not significantly prolong QTc interval in the overall infant group.
  • Clinically significant QTc prolongation occurred in a small subset of infants.
  • Routine QTc interval monitoring is recommended when initiating domperidone in infants.
Abstract

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