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Related Concept Videos

Sympathetic Signaling01:31

Sympathetic Signaling

Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...

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Dissection of Pelvic Autonomic Ganglia and Associated Nerves in Male and Female Rats
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Calbindin-D28k immunoreactivity in sympathetic ganglionic neurons during development.

Petr M Masliukov1, Alexandr A Korobkin, Alexandr D Nozdrachev

  • 1Department of Normal Physiology, Yaroslavl State Medical Academy, Yaroslavl, Russia. masliukov@rambler.ru

Autonomic Neuroscience : Basic & Clinical
|January 10, 2012
PubMed
Summary

The percentage of Calbindin-immunoreactive (CB-IR) neurons in sympathetic ganglia decreases significantly during early postnatal development in rats and cats, with changes stabilizing by one month in rats and two months in cats.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Immunohistochemistry

Background:

  • Calbindin (CB) is a calcium-binding protein found in various neuronal populations.
  • Sympathetic ganglia play crucial roles in the autonomic nervous system.
  • Understanding developmental changes in neuronal markers is vital for neuroscience research.

Purpose of the Study:

  • To investigate the developmental expression and distribution of Calbindin (CB) in rat and cat sympathetic ganglia.
  • To quantify changes in CB-immunoreactive (CB-IR) neurons during early postnatal life.
  • To compare CB expression patterns across different sympathetic ganglia (SCG, SG, CG) and species.

Main Methods:

  • Immunohistochemistry was used to detect CB immunoreactivity.
  • Sympathetic ganglia (SCG, SG, CG) were analyzed from rats and cats at various postnatal ages.
  • The percentage and size of CB-IR neurons were quantified and compared.

Main Results:

  • CB-IR neuron percentages decreased significantly from birth to 30 days in rats and cats.
  • In rats, the stellate ganglion (SG) consistently showed the highest percentage of CB-IR neurons.
  • In cats, CB-IR neurons decreased rapidly, with few remaining by two months; SG had the highest, CG the lowest percentage.

Conclusions:

  • CB expression in sympathetic ganglia undergoes significant developmental downregulation in both rats and cats.
  • Developmental changes in CB expression and neuron size are largely complete by one month in rats and two months in cats.
  • Species-specific differences exist in the rate and extent of CB expression changes in sympathetic ganglia.