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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

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Cobalamin deficiency presenting as obsessive compulsive disorder: case report.

Vivek Sharma¹, Devdutta Biswas

¹Department of Psychiatry, Kailash Hospital, Greater Noida, Uttar Pradesh, India. doc.v.sharma@hotmail.com

General Hospital Psychiatry

|January 10, 2012

Summary

Obsessive compulsive disorder (OCD) can be a rare symptom of vitamin B12 deficiency. Prompt diagnosis and methylcobalamin treatment led to symptom improvement in a patient with low cobalamin levels.

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Area of Science:

Neurology
Psychiatry
Nutritional Science

Background:

Cobalamin (vitamin B12) deficiency can cause diverse neuropsychiatric symptoms.
These symptoms may occur even without typical hematological changes like anemia.
Obsessive compulsive disorder (OCD) has not been previously linked to vitamin B12 deficiency.

Observation:

A middle-aged male presented with symptoms of OCD.
Laboratory tests revealed low serum cobalamin levels.
The patient had a family history of vitamin B12 deficiency.

Findings:

The patient's OCD symptoms showed significant improvement.
Treatment with methylcobalamin (vitamin B12) replacement was administered.
This suggests a potential causal link between vitamin B12 deficiency and OCD in this case.

Implications:

This case expands the known spectrum of neuropsychiatric manifestations of cobalamin deficiency.
It highlights the importance of considering vitamin B12 testing in patients with unexplained OCD.
Early diagnosis and treatment with vitamin B12 may alleviate psychiatric symptoms.