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[Insulin resistance in overweight cystic fibrosis paediatric patients]

D González Jiménez1, C Bousoño García, M F Rivas Crespo

  • 1Gastroenterología y Nutrición Pediátrica, Hospital Universitario Central de Asturias, Oviedo, España. domixixon@gmail.com

Anales De Pediatria (Barcelona, Spain : 2003)
|January 10, 2012
PubMed

Insights

Overweight children with cystic fibrosis (CF) show higher insulin resistance, indicating potential future diabetes risk despite similar blood sugar levels. This highlights the need for monitoring metabolic health in overweight CF patients.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Cystic Fibrosis Research

Context:

  • Cystic Fibrosis (CF) affects multiple organs, including metabolic regulation.
  • Overweight is an emerging concern in pediatric CF populations.
  • Insulin resistance is a known risk factor for type 2 diabetes.

Purpose:

  • To assess the prevalence of overweight in pediatric CF patients.
  • To investigate the association between overweight and insulin resistance.
  • To evaluate the risk of hypertriglyceridemia in overweight CF patients.

Summary:

  • A study of 109 pediatric CF patients (ages 5-18) found 5.5% were overweight.
  • Overweight CF patients exhibited higher baseline insulin, HOMA-IR, and insulin response during OGTT.
  • Despite similar glycaemic disorders, overweight was linked to hyperinsulinism and insulin resistance.

Impact:

  • Identifies overweight as a potential diabetogenic risk factor in CF.
  • Suggests closer metabolic monitoring for overweight pediatric CF patients.
  • Informs strategies for managing metabolic complications in CF.
Abstract

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