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Related Experiment Video

Updated: May 26, 2026

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14⁺ Monocytes

Published on: April 11, 2025

Tolerogenic dendritic cells: applications for solid organ transplantation.

Gaelle Beriou¹, Aurelie Moreau, Maria C Cuturi

¹INSERM UMR643, CHU Hotel-Dieu, 30 boulevard Jean Monnet, Nantes, France.

Current Opinion in Organ Transplantation

|January 10, 2012

Summary

Tolerogenic dendritic cells (TolDCs) show promise for solid organ transplantation. Autologous, unpulsed TolDC therapy is well-tolerated and may improve long-term allograft survival while reducing immunosuppression.

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Last Updated: May 26, 2026

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

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Published on: May 18, 2018

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Area of Science:

Immunology
Transplantation Medicine
Cell Therapy

Background:

Tolerogenic dendritic cells (TolDCs) are being explored for their potential to induce immune tolerance in transplantation.
Current strategies often involve donor-derived or antigen-pulsed dendritic cells, with varying success and potential risks.

Purpose of the Study:

To review the therapeutic applications of TolDCs in solid organ transplantation.
To emphasize recent experimental and preclinical data supporting clinical translation.
To evaluate strategies using autologous versus donor-derived or antigen-pulsed TolDCs.

Main Methods:

Review of experimental and preclinical data on TolDC therapy in transplantation.
Analysis of strategies involving donor dendritic cells, donor antigen-pulsed dendritic cells, and autologous dendritic cells.
Examination of clinical-grade human TolDC generation from monocytes.

Main Results:

TolDCs have demonstrated success in promoting long-term allograft survival in rodent models.
Autologous, unpulsed dendritic cells represent a potentially safer and clinically relevant approach.
Generation of clinical-grade human TolDCs from blood monocytes has been achieved.
Preliminary human data and critical implementation issues for TolDC therapy are discussed.

Conclusions:

TolDC therapy holds significant therapeutic promise for transplant recipients.
Autologous, unpulsed TolDC cell therapy is a well-tolerated and clinically relevant strategy.
This approach may enhance long-term allograft survival and mitigate the need for extensive immunosuppression.