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Multiple effects of tetrahydroaminoacridine on the cholinergic system: biochemical and behavioural aspects

A Adem1, A K Mohammed, B Winblad

  • 1Department of Geriatric Medicine, Karolinska Institute, Huddinge Hospital, Sweden.

Journal of Neural Transmission. Parkinson'S Disease and Dementia Section
|January 1, 1990
PubMed

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Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
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