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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: May 26, 2026

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Systemic lupus and malignancies.

Sasha Bernatsky1, Mruganka Kale, Rosalind Ramsey-Goldman

  • 1Division of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada. sasha.bernatsky@mail.mcgill.ca

Current Opinion in Rheumatology
|January 10, 2012
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) patients face higher risks for certain cancers like non-Hodgkin lymphoma and lung cancer. However, SLE may also decrease the risk of some nonhematologic cancers, indicating a complex relationship.

Related Experiment Videos

Last Updated: May 26, 2026

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Area of Science:

  • Rheumatology
  • Oncology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease associated with immune dysregulation.
  • Increased cancer susceptibility is a recognized concern in SLE patients.

Purpose of the Study:

  • To review the current understanding of cancer risks in individuals with SLE.
  • To identify specific cancer types with altered incidence in SLE patients.

Main Methods:

  • Literature review of studies examining cancer incidence in SLE.
  • Analysis of risk factors including immunosuppressive therapy and disease activity.

Main Results:

  • Elevated risk for non-Hodgkin lymphoma (NHL), lung cancer, and cervical dysplasia in SLE patients.
  • Immunosuppression and lupus disease activity are potential drivers of increased cancer risk.
  • Reduced risk observed for certain nonhematologic cancers (breast, ovarian, endometrial, prostate) in SLE.

Conclusions:

  • The relationship between SLE and cancer risk is multifaceted.
  • Further research is needed to fully elucidate the mechanisms and management strategies.