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Neonatal Pial Surface Electroporation
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Neonatal tetanus: a continuing challenge.

Ruchi Rai1, D K Singh

  • 1Department of Pediatrics, M. L. N. Medical College, Allahabad, U.P., India. drruchi.rai@indiatimes.com

Indian Journal of Pediatrics
|January 10, 2012
PubMed
Summary
This summary is machine-generated.

Neonatal tetanus (NT) remains a significant cause of infant mortality, with a 63% death rate in this study. Early symptom onset within a week of birth is a critical risk factor for mortality in newborns.

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Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Neonatal tetanus (NT) continues to pose a significant threat to infant survival, particularly in underserved regions.
  • Despite advances in maternal and neonatal care, NT contributes substantially to preventable neonatal deaths.

Purpose of the Study:

  • To analyze the clinical characteristics and mortality patterns of neonatal tetanus cases.
  • To identify risk factors associated with mortality in neonatal tetanus.

Main Methods:

  • Retrospective analysis of case records for newborns diagnosed with neonatal tetanus over 36 months.
  • Data collection included age of symptom onset, survival status, and mortality rates.

Main Results:

  • A total of 27 neonatal tetanus cases were identified, with an overall mortality rate of 63% (17 deaths).
  • The mean age of symptom onset was significantly lower in neonates who died (5.7 days) compared to survivors (8.1 days) (p=0.001).
  • Neonates with symptom onset before 7 days of life were nearly 5 times more likely to die.

Conclusions:

  • Neonatal tetanus remains a critical cause of neonatal mortality, especially in developing areas.
  • Early onset of symptoms within the first week of life is a strong predictor of mortality in neonatal tetanus.
  • Targeted interventions focusing on early detection and management are crucial for reducing NT-related deaths.