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Role of GERD in children with otitis media with effusion

Surendran Nair1, Madhumita Kumar, Prathapan Nair

  • 1Department of ENT, Amrita Institute of Medical Sciences and Research Centre, (AIMS), Ponekkara P.O., Kochi, Kerala 682041, India.

Indian Journal of Pediatrics
|January 10, 2012
PubMed

Insights

Gastroesophageal reflux disease (GERD) may contribute to otitis media with effusion (OME) in children, as pepsinogen was detected in middle ear fluid. However, a direct association between GERD symptoms and OME was not statistically significant.

Area of Science:

  • Otolaryngology
  • Pediatric Medicine
  • Gastroenterology

Background:

  • Otitis media with effusion (OME) is a common pediatric condition.
  • Gastroesophageal reflux disease (GERD) is a potential, yet unconfirmed, factor in OME pathogenesis.
  • Pepsinogen presence in middle ear fluid could indicate reflux aspiration.

Purpose of the Study:

  • To investigate the role of GERD in the development of OME.
  • To assess the correlation between GERD symptoms and OME.
  • To detect pepsinogen in middle ear effusion (MEE) and analyze its association with OME.

Main Methods:

  • Prospective study involving 32 children with OME undergoing surgery.
  • Collection and analysis of middle ear effusion samples for pepsinogen levels and total protein.
  • Electrophoresis (SDS-PAGE) to identify pepsinogen bands.

Main Results:

  • Pepsinogen levels exceeded the cutoff (90 mg/ml) in 21 out of 32 MEE samples.
  • No statistically significant association was found between GERD scores and pepsinogen levels (P=0.512).
  • Lack of GERD symptoms in the study cohort aligns with existing literature.

Conclusions:

  • OME is likely a multifactorial condition.
  • GERD is suggested as a potential contributing factor in OME etiology.
  • Further research is needed to fully elucidate the GERD-OME relationship.
Abstract

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