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Updated: May 26, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Electrolyte-stimulated biphasic dissolution profile and stability enhancement for tablets containing
Christoph Kindermann1, Karin Matthée, Frank Sievert
1Heinrich Heine University Duesseldorf, Duesseldorf, Germany. christoph.kindermann@uni-duesseldorf.de
Drug-polyelectrolyte complexes, prepared by hot-melt extrusion, offer tunable drug release profiles and enhanced stability in solid dosage forms. These complexes are activated by electrolyte concentration, providing immediate or prolonged naproxen release.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Drug-polyelectrolyte complexes (DPECs) offer potential for advanced drug delivery systems.
- Hot-melt extrusion (HME) is a viable technique for preparing DPECs with controlled properties.
Purpose of the Study:
- To investigate the stability enhancement potential of DPECs.
- To develop solid dosage forms with tailor-made release characteristics using DPECs.
Main Methods:
- Preparation of naproxen-EUDRAGIT® E PO DPECs via HME.
- Processing of DPECs into double-layer tablets with varying complex loadings.
- Assessment of physicochemical interactions, moisture sorption/desorption, and stability under ICH conditions.
Main Results:
- Naproxen release from DPECs is triggered by electrolyte concentration.
- Double-layer tablets exhibited biphasic dissolution profiles (immediate and prolonged release) dependent on complex loading.
- DPECs demonstrated stability in the amorphous state, unlike the pure drug which showed pseudopolymorphism.
Conclusions:
- DPECs enable the creation of solid dosage forms with electrolyte-stimulated, tailor-made dissolution profiles.
- DPECs enhance the stability of drugs in the amorphous state under common storage conditions.
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