Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cross-bridge Cycle01:26

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A synthetic bacterial community made of human milk isolated strains is an effective strategy to prevent food allergy in a mouse model.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Electrodiagnostic criteria for neuromuscular transmission disorders suggested by a European consensus group.

Clinical neurophysiology practice·2025
Same author

A Gestational Supplementation With 2'-Fucosyllactose Is an Effective Strategy to Prevent Food Allergy.

Allergy·2024
Same author

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2023
Same author

AM-879, a PPARy non-agonist and Ser273 phosphorylation blocker, promotes insulin sensitivity without adverse effects in mice.

Metabolism open·2023
Same author

Wasted leg syndrome: An atypical slowly-progressive form of lower motor neuron disease.

Revue neurologique·2022
Same journal

Early and severe masticatory muscle involvement in SOD1-ALS: a case report with biomarker-clinical dissociation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Early multimodal predictors of good neurological outcome in comatose patients after cardiac arrest: a prospective single-center cohort study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Telemedicine for headache disorders in real-world practice: from patient experience to health system impact.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Topography and functional connectivity analysis of heart surgery-associated brain lesions: a literature review.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Limb apraxia in Parkinson's disease and atypical parkinsonian syndromes: a systematic review.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Primary Sjogren syndrome with suspected central nervous system inflammatory involvement.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Exercise and amyotrophic lateral sclerosis.

J P Lopes de Almeida1, R Silvestre, A C Pinto

  • 1Department of Physical Medicine and Rehabilitation, University of Lisbon Medical School, Santa Maria Hospital, Lisbon, Portugal. jpedro.gla@gmail.com

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|January 10, 2012
PubMed
Summary
This summary is machine-generated.

Physical exercise offers significant benefits for individuals with Amyotrophic Lateral Sclerosis (ALS), improving survival and quality of life. Overcoming sedentary barriers is crucial for maximizing these advantages in ALS patients.

More Related Videos

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury
10:49

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Published on: September 18, 2011

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)
12:35

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Published on: March 17, 2012

Related Experiment Videos

Last Updated: May 26, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury
10:49

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Published on: September 18, 2011

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)
12:35

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Published on: March 17, 2012

Area of Science:

  • Neurology
  • Neurodegenerative Diseases
  • Rehabilitation Medicine

Background:

  • Amyotrophic Lateral Sclerosis (ALS) is a progressive, fatal neurodegenerative disease with a significant impact on end-of-life care.
  • Physical exercise can provide physiological and psychological benefits, particularly in earlier stages of ALS, by combating muscle disuse atrophy and preserving mobility and cardiovascular fitness.
  • Historically, exercise in neuromuscular conditions like ALS has been controversial due to patient inactivity and weakness, necessitating further clinical investigation.

Purpose of the Study:

  • To critically evaluate the risks and benefits of physical exercise in patients with Amyotrophic Lateral Sclerosis (ALS).
  • To address the need for controlled clinical trials to clarify the role of exercise in managing ALS.
  • To explore strategies for overcoming sedentary barriers and enhancing health-related quality of life in ALS patients through exercise.

Main Methods:

  • Review of recent research studies documenting the effects of exercise in ALS.
  • Analysis of challenges in current research, including poor cooperation, small sample sizes, and short trial durations.
  • Identification of potential supportive measures like body-weight support systems and non-invasive ventilation to facilitate exercise.

Main Results:

  • Recent studies indicate significant benefits of exercise for ALS patients, including improved survival rates and enhanced quality of life.
  • Despite documented benefits, research is hampered by factors such as patient cooperation, sample size limitations, and trial duration.
  • Exercise, when adapted to overcome limitations like fatigue, can be a valuable component of care.

Conclusions:

  • Physical exercise demonstrates considerable potential for improving outcomes in Amyotrophic Lateral Sclerosis (ALS).
  • Controlled clinical trials are essential to definitively establish the efficacy and safety of exercise interventions in ALS.
  • Overcoming sedentary barriers through supportive technologies is key to integrating exercise as a beneficial strategy for ALS management and improving health-related quality of life.