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Related Concept Videos

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

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Related Experiment Video

Updated: May 26, 2026

In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

Infections associated with spinal implants.

Andrew Quaile1

  • 1Division of Spinal Orthopaedics, Hampshire Clinic, Old Basing, Basingstoke, United Kingdom. andrew@spine-works.com

International Orthopaedics
|January 10, 2012
PubMed
Summary

Managing spinal infections, especially with implants, requires early diagnosis and multidisciplinary care. The focus is shifting towards retaining implants when possible, balancing stability and neurological function.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Spinal Medicine

Background:

  • Spinal infections present significant clinical challenges, particularly when implants are present.
  • The spine's unique requirements for stability and neurological protection complicate infection management compared to general orthopedics.
  • Newer spinal procedures like disc replacement introduce access challenges for infection treatment.

Purpose of the Study:

  • To review the current literature on managing spinal infections in the context of orthopedic implants.
  • To highlight the evolving treatment strategies, emphasizing implant retention.
  • To discuss novel and established methods for infection prevention and management in spinal surgery.

Main Methods:

  • Literature review of current practices and research on spinal infections.

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In Vivo Mouse Model of Spinal Implant Infection
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Animal Model of Implant-Associated Infections in Mice
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Animal Model of Implant-Associated Infections in Mice

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  • Analysis of challenges posed by implants and new surgical techniques.
  • Examination of diagnostic and management strategies, including multidisciplinary approaches.

    • Main Results:

    • A shift in practice towards retaining spinal implants whenever feasible.
    • Recognition of increased difficulty in managing infections with newer spinal procedures due to access.
    • Emphasis on early diagnosis, high suspicion, and aggressive, multidisciplinary management.

    Conclusions:

    • Early diagnosis and a high index of suspicion are crucial for effective spinal infection management.
    • Multidisciplinary collaboration is essential for optimal outcomes in treating spinal infections, especially with implants.
    • Preventative strategies and innovative wound closure techniques are vital for minimizing infection risk and improving patient care.