Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemerin knockout reveals sex difference in the role of chemerin in blood pressure and vascular remodeling.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Developing And Internally Validating AI-Based Aging Resilience Biomarkers in Non-Human Primates.

bioRxiv : the preprint server for biology·2026
Same author

Developing and internally validating AI-based aging resilience biomarkers in non-human primates.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

Surgical Induction of Mid-Thoracic Aortic Coarctation in Mice: A Reproducible Preclinical Model of Pressure-Induced Vascular Remodeling.

Current protocols·2026
Same author

Identification of putative kidney-derived proteins in plasma using nanoparticle enrichment.

Molecular omics·2026
Same author

MicroRNA Regulatory Targets Related to VO<sub>2</sub>peak Decline in Older Adult Participants of the Study of Muscle, Mobility and Aging (SOMMA).

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: May 26, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

A custom rat and baboon hypertension gene array to compare experimental models.

Carrie A Northcott1, Jeremy P Glenn, Robert E Shade

  • 1Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA. taetscar@msu.edu

Experimental Biology and Medicine (Maywood, N.J.)
|January 10, 2012
PubMed
Summary

Researchers developed a novel gene array to compare hypertension-related genes across species. This tool aids in understanding human hypertension by analyzing gene expression in rat and baboon kidneys, revealing key differences and similarities.

More Related Videos

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
08:27

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.

Published on: January 27, 2015

Related Experiment Videos

Last Updated: May 26, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
08:27

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.

Published on: January 27, 2015

Area of Science:

  • Genomics
  • Cardiovascular Disease Research
  • Comparative Biology

Background:

  • Hypertension is a complex polygenic disease influenced by environmental factors.
  • Translating findings from animal models to human hypertension is challenging due to biological differences and technological limitations.
  • A need exists for a platform to directly compare hypertension-relevant genes across species.

Purpose of the Study:

  • To design and validate a single-array platform for comparing hypertension-related gene expression.
  • To assess the utility of this platform in comparing gene expression between normotensive rats and baboons.
  • To evaluate the array's performance in a pathological condition using a rat model of hypertension.

Main Methods:

  • Development of a custom gene array targeting 328 genes associated with blood pressure control.
  • Comparison of kidney gene expression between normotensive rats and baboons.
  • Analysis of kidney gene expression in the deoxycorticosterone acetate (DOCA)-salt rat model of hypertension versus sham controls.

Main Results:

  • Identified 74 commonly expressed genes, 41 rat-specific, and 34 baboon-specific genes in normotensive kidneys.
  • In the DOCA-salt hypertension model, three genes (annexin A1, glutamate-cysteine ligase, glutathione-S transferase) were differentially expressed in the renal cortex.
  • Twenty-one genes showed differential expression in the renal medulla of hypertensive rats.

Conclusions:

  • The developed array platform enables direct comparison of hypertension-related genes across species.
  • Few genes were differentially expressed in the kidney during DOCA-salt hypertension, suggesting a role for limited gene-by-environment interactions.
  • This platform facilitates a more accurate understanding of human hypertension by bridging animal model and human studies.