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Updated: May 26, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor

Youngwook Kim1, Jeonghun Ko, ZhengYun Cui

  • 1Medical Nano-Element Development Center, Samsung Biomedical Research Institute, Seoul, Korea.

Molecular Cancer Therapeutics
|January 10, 2012
PubMed

Insights

Acquired resistance to irreversible EGFR inhibitors in non-small cell lung cancer (NSCLC) can occur through secondary T790M mutations. Current second-generation EGFR inhibitors may not fully prevent EGFR-dependent signaling in resistant cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective for EGFR-mutant non-small cell lung cancer (NSCLC).
  • Acquired resistance to these reversible TKIs necessitates the development of second-generation, irreversible EGFR inhibitors.
  • The mechanisms underlying acquired resistance to irreversible EGFR inhibitors remain largely unclear.

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