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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

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Related Experiment Video

Updated: May 26, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Methicillin-resistant Staphylococcus pseudintermedius isolated from canine pyoderma in North China.

Y Wang1, J Yang, C M Logue

  • 1Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Journal of Applied Microbiology
|January 11, 2012
PubMed
Summary

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) was found in 12.7% of dogs with pyoderma in North China. The study identified two main MRSP clonal lineages, ST71 and ST5, highlighting a significant veterinary challenge.

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Last Updated: May 26, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Veterinary Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Canine pyoderma is a common skin infection.
  • Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an emerging pathogen in veterinary medicine.
  • Limited data exists on MRSP prevalence in China.

Purpose of the Study:

  • To determine the prevalence of MRSP in dogs with pyoderma in North China.
  • To characterize MRSP isolates from these dogs.
  • To provide baseline data for future surveillance.

Main Methods:

  • Swabs collected from 260 dogs with pyoderma.
  • Phenotypic and genotypic confirmation of MRSP.
  • Characterization using MLST, spa typing, SCC mec typing, antimicrobial susceptibility testing, and PFGE.

Main Results:

  • MRSP was detected in 12.7% (33/260) of dogs.
  • The most common MRSP genotypes were ST71-t06-II-III (66.7%) and ST5-t19 (24.2%).
  • All MRSP isolates exhibited extended antimicrobial resistance.

Conclusions:

  • Clinical MRSP isolates in North China belong to two major clonal lineages: ST71 and ST5.
  • This is the first report of MRSP from canine pyoderma in China.
  • Further surveillance is recommended to address this clinical challenge.