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Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

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Related Experiment Video

Updated: May 26, 2026

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
08:59

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions

Published on: April 18, 2015

Dupuytren's disease.

Michael Worrell1

  • 1Department of Orthopedic Surgery, Mercy St Vincent Medical Center, Toledo, Ohio, USA.

Orthopedics
|January 11, 2012
PubMed
Summary
This summary is machine-generated.

Dupuytren's disease, a hand disorder, is increasingly treated with less invasive methods like enzymatic fasciotomy. New data suggests these approaches, alongside specific rehabilitation, offer improved outcomes for patients.

Related Experiment Videos

Last Updated: May 26, 2026

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
08:59

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions

Published on: April 18, 2015

Area of Science:

  • Hand surgery
  • Musculoskeletal disorders

Background:

  • Dupuytren's disease is a benign hand contracture disorder.
  • Its etiology involves fibroproliferation and collagen changes, but the exact cause is unknown.
  • Older men of Celtic descent are commonly affected.

Purpose of the Study:

  • To review current and emerging treatments for Dupuytren's disease.
  • To evaluate the efficacy of less invasive techniques compared to traditional surgery.
  • To outline optimal postoperative rehabilitation strategies.

Main Methods:

  • Review of current literature and phase III study data.
  • Comparison of open fasciectomy with needle aponeurotomy and enzymatic fasciotomy.
  • Analysis of postoperative rehabilitation protocols.

Main Results:

  • Open fasciectomy remains a primary treatment but has associated morbidity and recurrence.
  • Less invasive techniques, such as enzymatic fasciotomy with injectable collagenase, show promise.
  • Phase III study data is influencing treatment algorithms.

Conclusions:

  • Injectable collagenase and enzymatic fasciotomy represent evolving, less invasive treatment options for Dupuytren's disease.
  • Postoperative rehabilitation, including splinting and active range of motion exercises, is crucial for functional recovery.