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Updated: May 26, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

A new reagent for direct difluoromethylation.

Yuta Fujiwara1, Janice A Dixon, Rodrigo A Rodriguez

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 11, 2012
PubMed
Summary

A new reagent, difluoromethyl zinc (DFMS), enables efficient difluoromethylation of organic molecules. This radical process is mild, scalable, and works for various complex substrates like heteroarenes and thiols.

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