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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease
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[Bone disease in Gaucher's disease].

Mercedes Roca Espiau1

  • 1Centro de Diagnóstico por Imagen, Zaragoza, Spain. mroca12@gmail.com

Medicina Clinica
|January 11, 2012
PubMed
Summary

This review explores Gaucher cell bone marrow infiltration, detailing qualitative and quantitative imaging methods like MRI and DEXA for assessing disease progression and treatment response.

Area of Science:

  • Hematology
  • Radiology
  • Medical Imaging

Context:

  • Gaucher disease involves Gaucher cell accumulation in bone marrow.
  • Understanding bone marrow involvement is crucial for disease management.

Purpose:

  • To review pathophysiological mechanisms of bone marrow involvement in Gaucher disease.
  • To assess various methods for evaluating bone marrow infiltration and its progression.

Summary:

  • Qualitative methods include radiography, MRI, CT, and radioisotopes for assessing bone remodeling, infiltration, complications, and differential diagnoses.
  • Quantitative methods like quantitative chemical shift imaging (QCSI) and DEXA measure bone marrow fat content and bone density.
  • Semi-quantitative scoring systems aid in evaluating generalized bone disease, progression, and therapeutic response.

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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

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Last Updated: May 26, 2026

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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

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Impact:

  • Provides a comprehensive overview of imaging techniques for Gaucher disease bone marrow assessment.
  • Aids clinicians in selecting appropriate methods for monitoring disease progression and treatment efficacy.
  • Highlights the evolving role of advanced imaging in managing Gaucher disease complications.