Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 26, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Altering the immune response with lipid-based nanoparticles.

Dalit Landesman-Milo1, Dan Peer

  • 1Laboratory of Nanomedicine, Dept. of Cell Research and Immunology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv 69978, Israel Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, 69978, Israel.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 11, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid nanoparticles engineered to target therapeutic RNA to the pancreas.

Nature·2026
Same author

The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.

Drug delivery and translational research·2026
Same author

A symphony of immunity: How HPV mRNA-LNP vaccination orchestrates systemic anti-tumor responses.

Molecular therapy. Nucleic acids·2026
Same author

cSMRTS for cancer therapeutics.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

On The Retrograde Transport of RNA-Loaded Lipid Nanoparticles Designed for Brain Delivery.

ACS nanoscience Au·2025
Same author

The impact of chemical reactivity on the quality and stability of RNA-LNP pharmaceuticals.

Nature reviews. Chemistry·2025
Same journal

Endogenous-metabolite-inspired polyamine-oleic acid lipids for safe mRNA delivery and PCSK9 gene editing.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Tunable rigid spikes on virus-like porous silica enable mechanistically controlled nanovaccine platforms.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

New approach methodologies (NAMs) for preclinical and translational evaluation of mRNA-lipid nanoparticle (LNP) therapeutics.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

A cation-free platform based on azocalixarene poly(disulfide)s for direct cytosolic protein delivery.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Harnessing plant-derived extracellular vesicles for oral delivery: A dual role as natural therapeutics and engineered drug carriers.

Journal of controlled release : official journal of the Controlled Release Society·2026
See all related articles

Lipid-based nanoparticles (LNPs) are promising drug delivery systems. Understanding their interactions with immune cells (leukocytes) is crucial for optimizing cancer, inflammation, and infection treatments and minimizing side effects.

Area of Science:

  • Biomedical Engineering
  • Immunology
  • Nanotechnology

Background:

  • Lipid-based nanoparticles (LNPs) are advanced drug delivery systems with established clinical applications.
  • LNPs are engineered to enhance drug pharmacokinetics, biodistribution, stability, and therapeutic efficacy while minimizing adverse effects.
  • Biocompatibility, non-toxicity, and controlled immune system interaction are critical for LNP efficacy.

Purpose of the Study:

  • To investigate the complex interactions between lipid-based nanoparticles (LNPs) and various leukocyte subsets.
  • To elucidate how LNPs can either suppress or activate components of the innate and adaptive immune systems.
  • To provide a foundation for designing safer and more effective LNP-based therapeutics.

Main Methods:

  • Review of existing literature on LNP-leukocyte interactions.

More Related Videos

Intra-lymph Node Injection of Biodegradable Polymer Particles
09:06

Intra-lymph Node Injection of Biodegradable Polymer Particles

Published on: January 2, 2014

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Related Experiment Videos

Last Updated: May 26, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Intra-lymph Node Injection of Biodegradable Polymer Particles
09:06

Intra-lymph Node Injection of Biodegradable Polymer Particles

Published on: January 2, 2014

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

  • Analysis of studies detailing LNP-mediated immune suppression and activation.
  • Examination of LNP interactions with both innate and adaptive immune cells.

    • Main Results:

    • LNPs exhibit diverse interactions with different leukocyte populations.
    • Evidence suggests LNPs can modulate immune responses, leading to either suppression or activation.
    • Specific LNP characteristics influence the nature and extent of immune engagement.

    Conclusions:

    • Thorough understanding of LNP-immune system interplay is essential for maximizing therapeutic benefits.
    • Investigating LNP interactions with leukocytes can guide the development of targeted therapies for cancer, inflammation, and infections.
    • Harnessing LNP immunomodulatory properties may lead to reduced immune toxicity and improved treatment outcomes.