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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Inflammation01:38

Inflammation

Overview
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: May 26, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Atherosclerosis: a classic inflammatory disease.

A Anogeianaki, D Angelucci, E Cianchetti

    International Journal of Immunopathology and Pharmacology
    |January 11, 2012
    PubMed
    Summary

    Atherosclerosis involves immune cells like macrophages and T cells infiltrating blood vessel walls, driving inflammation. This study clarifies the complex relationship between atherosclerosis and the immune system

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    Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
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    Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

    Published on: October 25, 2024

    Related Experiment Videos

    Last Updated: May 26, 2026

    A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
    05:51

    A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

    Published on: May 6, 2014

    Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
    09:55

    Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

    Published on: October 25, 2024

    Area of Science:

    • Immunology
    • Cardiovascular Science

    Background:

    • Atherosclerosis is an inflammatory condition linked to diet, obesity, and high cholesterol.
    • It involves macrophage and T cell infiltration into vascular walls, promoting inflammation.

    Discussion:

    • Activated macrophages secrete cytokines (TNF, IL-1) and chemokines (RANTES), amplifying the inflammatory response.
    • Matrix metalloproteinase-9 (MMP-9) is also produced by activated monocytes.

    Key Insights:

    • The study revisits the intricate connection between atherosclerosis and the immune system.
    • Understanding immune cell roles is crucial for comprehending disease progression.

    Outlook:

    • Further research is needed to fully elucidate the immune system's role in atherosclerosis.
    • Targeting specific immune pathways may offer novel therapeutic strategies.