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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
The challenge of post-implementation surveillance for novel meningococcal vaccines
Matthew D Snape1, Duccio Medini, Scott A Halperin
1Oxford Universities Hospitals NHS Trust, United Kingdom. matthew.snape@paediatrics.ox.ac.uk
Abstract:
Novel serogroup B meningococcal vaccines are currently in late stage development and may be used in mass immunisation campaigns over the coming years. This represents an exciting development in the prevention of childhood meningitis, however monitoring the impact of these vaccines on meningococcal disease epidemiology will provide significant challenges. Although designed to prevent serogroup B meningococcal disease the vaccine antigens are not serogroup specific, creating the potential for multiple definitions of vaccine effectiveness and vaccine failure.
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