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The Oral Microbiota01:27

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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
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Fluoride bioavailability in saliva and plaque.

Ella A Naumova1, Phillip Kuehnl, Philipp Hertenstein

  • 1Faculty of Health, Department of Dentistry, University of Witten/Herdecke, Alfred Herrhausenstrasse 50, 58448 Witten, Germany.

BMC Oral Health
|January 11, 2012
PubMed
Summary

This study found no significant difference in how sodium fluoride (NaF) and amine fluoride affect fluoride levels in saliva and plaque. Both formulations showed similar bioavailability and returned to baseline levels within six hours after brushing.

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Area of Science:

  • Biochemistry
  • Dental Research
  • Pharmacokinetics

Background:

  • Different fluoride formulations may impact caries prevention differently.
  • Assessing fluoride delivery from sodium fluoride (NaF) versus amine fluoride is crucial for understanding caries prevention strategies.

Purpose of the Study:

  • To compare the fluoride content in saliva and plaque after using NaF versus amine fluoride.
  • To evaluate the bioavailability and retention of fluoride from different formulations.

Main Methods:

  • Eight volunteers used either NaF or amine fluoride toothpaste for 3 minutes.
  • Saliva and plaque samples were collected at multiple time points over 6 hours post-brushing.
  • Fluoride levels were analyzed using a fluoride-sensitive electrode and statistical analysis.

Main Results:

  • Fluoride concentrations in saliva and plaque initially increased post-brushing, returning to baseline within 6 hours.
  • No significant differences in fluoride bioavailability were observed between NaF and amine fluoride in either saliva or plaque.
  • Individual fluoride profiles in saliva and plaque showed high variability.

Conclusions:

  • Fluoride levels in saliva and plaque exhibit significant inter-individual variability.
  • Both NaF and amine fluoride demonstrate comparable fluoride bioavailability and retention in saliva and plaque.
  • The findings suggest similar efficacy of NaF and amine fluoride in terms of short-term fluoride delivery.