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Updated: May 26, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
A reduced dose of darunavir/ritonavir is effective in PI-experienced HIV-infected patients
Massimiliano Lanzafame1, Stefano Bonora, Emanuela Lattuada
1Infectious Diseases Unit, G.B. Rossi Hospital, Via piazzale L. Scuro 10, Verona, Italy. lanzafame.massimiliano@gmail.com
Abstract:
Darunavir (DRV) is an HIV-1 protease inhibitor that is used together with a low boosting dose of ritonavir as part of an antiretroviral therapy (ART) regimen in treatment-experienced and naïve HIV-positive patients. In naïve and experienced patients with no DRV-mutations, DRV is licensed at the dose of 800 mg plus 100 mg of ritonavir once daily. We report our results in seven ART-experienced HIV-infected patients, in whom a reduced dose of darunavir/ritonavir (600/100 mg once daily) successfully controlled viral replication.
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