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RA in 2011: Advances in diagnosis, treatment and definition of remission
1Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. gerd.burmester@charite.de
Nature Reviews. Rheumatology
|January 11, 2012
Abstract:
Evidence presented in 2011 suggests that rheumatoid arthritis might comprise two separate diseases—each with different etiological underpinnings—and that kinase inhibitors could soon be added to the therapeutic armamentarium. Together with new definitions of remission, these advances could aid the development of personalized, treat-to-target strategies.
Insights
Rheumatoid arthritis may be two distinct diseases with different causes. Kinase inhibitors and new remission definitions could enable personalized treatment strategies.
Area of Science:
- Rheumatology
- Immunology
- Pharmacology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease.
- Current understanding suggests a single disease entity.
- Existing treatments aim for remission but may not be universally effective.
Purpose of the Study:
- To explore the hypothesis that rheumatoid arthritis comprises two distinct disease subtypes.
- To evaluate the potential of kinase inhibitors as a therapeutic option for RA.
- To assess the impact of new remission definitions on treatment strategies.
Main Methods:
- Review of evidence presented in 2011 regarding RA classification.
- Analysis of the role and potential efficacy of kinase inhibitors in RA treatment.
- Evaluation of novel remission criteria in the context of RA management.
Main Results:
- Evidence suggests RA may represent at least two separate diseases with differing etiological factors.
- Kinase inhibitors show promise for future RA therapeutic strategies.
- New definitions of remission are proposed.
Conclusions:
- Rheumatoid arthritis may require distinct therapeutic approaches based on underlying etiology.
- Personalized, treat-to-target strategies are likely to be enhanced by emerging therapies and definitions.
- Advances in understanding RA could lead to more tailored patient care.
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