Related Experiment Video
Updated: May 26, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Developing an algorithm for pulse oximetry derived respiratory rate (RR(oxi)): a healthy volunteer study.
Paul S Addison1, James N Watson, Michael L Mestek
1Advanced Research Group, Covidien Respiratory and Monitoring Solutions, Technopole Centre, Edinburgh, EH26 0PJ, UK. Paul.Addison@Covidien.com
The novel RR(OXI) algorithm accurately extracts respiratory rate from photoplethysmography (PPG) signals. This technology offers a viable method for continuous respiratory monitoring in healthy individuals.
Area of Science:
- Biomedical Engineering
- Physiological Monitoring
- Signal Processing
Background:
- Respiratory information is present in photoplethysmography (PPG) signals.
- Extracting respiratory rate requires advanced signal processing and infrastructure.
- A holistic algorithmic approach is necessary for accurate respiratory rate monitoring.
Purpose of the Study:
- To introduce and evaluate the RR(OXI) algorithm for respiratory rate measurement.
- To assess the performance of the RR(OXI) algorithm using data from healthy subjects.
Main Methods:
- Collected finger PPG signals from 139 healthy adult volunteers.
- Processed PPG signals using a novel algorithm based on continuous wavelet transform.
- Compared computed oximeter respiratory rates (RR(oxi)) against end-tidal CO2 reference rates (RR(ETCO2)).
Main Results:
- RR(ETCO2) values ranged from 2.97 to 28.02 breaths/min (mean 14.49, SD 4.36).
- Excellent agreement was observed between RR(oxi) and RR(ETCO2) (mean difference -0.23, SD 1.14).
- A strong correlation (R2 = 0.93) was found between the two measurement methods.
Conclusions:
- The RR(OXI) algorithm demonstrates a viable technology for measuring respiratory rate.
- This method is suitable for continuous respiratory monitoring in healthy individuals.
Related Concept Videos
Special considerations while measuring oxygen saturation
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is important.
Pulse Oximetry
Purpose
Average SpO2 values are greater than 95%. If the readings fall below 90%, it indicates that...
Assessment of Ventilation I: Respiratory Rate
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
Guidelines For Measuring Vital Signs
Before taking a patient's vital signs, a nurse would consider and assess the patient's comfort level and ensure appropriate equipment is available.
Assessment of Respiration
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like asthma or COPD,...
Assessment of Ventilation II: Respiratory Depth and Rhythm
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:

