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Updated: Feb 10, 2026
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Infrared Thermography for the Detection of Changes in Brown Adipose Tissue Activity
Published on: September 28, 2022
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Detecting brown adipose tissue activity with BOLD MRI in mice
1Chemistry Department, French Family Science Center, Duke University, Durham, North Carolina 27708-0346, USA.
Magnetic Resonance in Medicine
|January 11, 2012
Summary
Researchers explored using blood-oxygen-level-dependent MRI to detect active brown adipose tissue (BAT) in adults. Findings suggest this method can noninvasively identify BAT activity, potentially aiding obesity research.
Area of Science:
- Biomedical Imaging
- Metabolic Research
- Human Physiology
Background:
- Active brown adipose tissue (BAT) in adult humans is linked to metabolic rate.
- BAT's role in human obesity is suspected but difficult to study noninvasively.
- Few imaging techniques exist to detect human BAT activity.
Purpose of the Study:
- To investigate the feasibility of using blood-oxygen-level-dependent (BOLD) MRI for detecting BAT activity.
- To explore BOLD MRI as a noninvasive tool for human BAT research.
Main Methods:
- Utilized BOLD MRI to assess changes in tissue oxygenation.
- Monitored signal changes in BAT following activation.
Main Results:
- BAT activation led to increased oxygen consumption.
- A localized signal drop in BAT was observed, correlating with increased deoxyhemoglobin levels.
- BOLD MRI successfully detected localized signal changes in BAT.
Conclusions:
- BOLD MRI shows promise as a noninvasive method for detecting human BAT activity.
- This technique could advance research into BAT's role in obesity and metabolism.
![Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62460.jpg&w=3840&q=50)
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