Methods in drug abuse models: comparison of different models of methamphetamine paradigms

Methamphetamine (METH) is a widely abused psychomotor stimulant. Investigating the effects of METH use on the brain has been applied in different animal models, including rats, mice, and nonhuman primates. Human abuse of METH occurs in different paradigms ranging from episodes of binge abuse to chronic abuse over years; different animal models have been established to replicate these various patterns of human behavior. In this chapter, we discuss the different models of METH abuse, including the acute model which assesses the immediate effects of METH on the brain and chronic exposure model which simulates the more common long-term use observed in humans; additionally, two other relevant models, escalating dose paradigm and METH self-administration, are examined. In comparing the models, this chapter briefly considers the METH-induced neurotoxic effects associated with each METH administration paradigm and the behavioral changes observed.