Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mitigation of activity-based anorexia by obese adipose tissue transplant is abolished by neonatal AgRP neuron ablation.

Translational psychiatry·2026
Same author

The attenuation of activity-based anorexia by obese adipose tissue transplant is AgRP neuron-dependent.

bioRxiv : the preprint server for biology·2024
Same author

Sex differences in risk-based decision-making and the modulation of risk preference by dopamine-2 like receptors in rats.

Neuropharmacology·2024
Same author

Identification of adipose tissue transcriptomic memory of anorexia nervosa.

Molecular medicine (Cambridge, Mass.)·2023
Same author

Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating.

PloS one·2023
Same author

Overlapping Neural Circuitry Links Cognitive Flexibility and Activity-Based Anorexia.

Biological psychiatry·2021

Related Experiment Video

Updated: May 1, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.2K

The activity-based anorexia mouse model.

Stephanie J Klenotich1, Stephanie C Dulawa

  • 1Committee on Neurobiology, University of Chicago, Chicago, IL, USA.

Methods in Molecular Biology (Clifton, N.J.)
|January 11, 2012
PubMed
Summary
This summary is machine-generated.

Activity-based anorexia (ABA) in mice, a model for anorexia nervosa (AN), shows reduced food intake and increased wheel running. This research provides guidelines for ABA experiments to understand AN neurobiology and find treatments.

More Related Videos

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

11.7K
Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
05:15

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms

Published on: January 10, 2025

1.6K

Related Experiment Videos

Last Updated: May 1, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.2K
Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

11.7K
Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
05:15

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms

Published on: January 10, 2025

1.6K

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Psychiatry

Background:

  • Activity-based anorexia (ABA) is a phenomenon where animals with running wheels and food restriction paradoxically reduce food intake and increase activity.
  • ABA leads to significant weight loss and can be fatal, mirroring aspects of anorexia nervosa (AN).
  • Anorexia nervosa is a severe psychiatric illness with high mortality and limited treatment options, necessitating better understanding of its mechanisms.

Purpose of the Study:

  • To provide guidelines for conducting activity-based anorexia experiments in mice.
  • To establish the ABA mouse model as a tool for studying the neurobiological basis of AN-like behaviors.
  • To facilitate the identification of novel therapeutic strategies for anorexia nervosa.

Main Methods:

  • Utilizing mice housed with running wheels.
  • Implementing daily food restriction protocols.
  • Observing and measuring food intake and running wheel activity.

Main Results:

  • Paradoxical reductions in food intake were observed.
  • Significant increases in running wheel activity were documented.
  • Marked reductions in body weight were noted, indicative of ABA.

Conclusions:

  • The ABA mouse model is a valuable tool for investigating the neurobiological underpinnings of anorexia nervosa.
  • ABA research can contribute to understanding the mechanisms driving AN-like behaviors.
  • This model holds potential for identifying and testing new treatments for AN.