Related Experiment Video
Updated: May 26, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
Published on: May 17, 2024
Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously
Ardiansyah1, Eri Yamaguchi, Hitoshi Shirakawa
1Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. ardy@biochem.tohoku.ac.jp
Abstract:
Supplementation with lupeol (0.67 g·kg(-1)) of the AIN-93M-based diet fed for 7 weeks to stroke-prone spontaneously hypertensive rats caused significantly decreased blood pressure as compared with a control group. Urinary 8-hydroxy-2'-deoxyguanosine was significantly lower in the lupeol group. Finally, lupeol suppressed the hepatic mRNA expression levels of the genes involved in triglyceride and cholesterol synthesis.

