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ERK pathway activation bidirectionally affects visual recognition memory and synaptic plasticity in the perirhinal

Davide Silingardi1, Andrea Angelucci, Roberto De Pasquale

  • 1Istituto di Neuroscienze del CNR Pisa, Italy.

Frontiers in Behavioral Neuroscience
|January 11, 2012
PubMed
Summary

The ERK 1,2 pathway in the perirhinal cortex (PRHC) is crucial for long-term recognition memory. Modulating this pathway bidirectionally affects memory consolidation and synaptic plasticity.

Keywords:
ERK1,2perirhinal cortexrecognition memorysynaptic plasticity

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cognitive Science

Background:

  • The ERK 1,2 pathway is vital for experience-dependent gene transcription and synaptic plasticity.
  • The perirhinal cortex (PRHC) is essential for familiarity-based object recognition memory.
  • The role of ERK activation in PRHC for recognition memory consolidation remains unclear.

Purpose of the Study:

  • To investigate if ERK activation in the PRHC is necessary for recognition memory consolidation.
  • To determine if modulating ERK pathway gain bidirectionally affects visual recognition memory and PRHC synaptic plasticity.

Main Methods:

  • Pharmacological blockade of ERK activation in the PRHC of adult mice.
  • Behavioral testing using the object recognition task (ORT) in Ras-GRF1 knock-out (KO) and ERK1 KO mice.
  • Electrophysiological analysis of long-term depression (LTD) and long-term potentiation (LTP) in PRHC slices.

Main Results:

  • Pharmacological ERK blockade in PRHC impaired long-term recognition memory.
  • Ras-GRF1 KO mice showed impaired long-term memory and memory reconsolidation, with reduced LTP and LTD in PRHC.
  • ERK1 KO mice demonstrated enhanced long-term recognition memory and enhanced LTP and LTD in PRHC.

Conclusions:

  • ERK 1,2 pathway activation in the PRHC is necessary for long-term recognition memory consolidation.
  • Modulating ERK pathway gain bidirectionally influences recognition memory and PRHC synaptic plasticity.
  • Findings suggest ERK pathway modulation as a potential therapeutic target for memory disorders.