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Updated: May 26, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[Family based association study of MMP-9 gene-1562C>T polymorphism in schizophrenia]
Agata Groszewska1, Paweł Kapelski, Maria Skibińska
1Zakiad Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu.
Aim:
MMP-9 is a candidate gene related to the neurodevelopment hypothesis of schizophrenia. The aim of this research was TDT analysis of polymorphism -1562C>T MMP-9 gene in schizophrenia.
Methods:
Research was carried out on 147 trios (patient and his/hers both healthy parents). Genetic material was isolated from leukocytes using the salting out method. Polymorphism was studied with PCR-RFLP, statistic analysis was made using transmission disquilibrium test by Haploview 4.2.
Results:
There was no significant association between analyzed polymorphism of MMP-9 (-1562 C>T) and schizophrenia.
Conclusions:
Insignificant association doesn't exclude the possible contribution of MMP-9 to pathogenesis of schizophrenia. Further research is needed to be carried out on bigger groups and other populations.
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