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Published on: May 26, 2023
[Study on Chinese herbs' volatile oil micro-emulsions by means of pseudo-ternary phase diagram]
Meng-Meng Yang1, Yan Zhang, Xin-You Liu
1Department of Pharmaceutics, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China. ymengmeng1980@163.com
Objective:
To optimize the formulation of Chinese herbs' volatile oil micro emulsion.
Methods:
Sreened the formulation of blank micro-emulsion and the formulation of micro-emulsion contained volatile oil by means of pseudo-ternary phase diagram.
Results:
System of isopropyl myristate, polyoxyethylene hydrogenated castor oil, absolute ethyl alcohol and water could formed the largest area of micro-emulsion. The optimal formulation of micro-emulsion contained volatile oil was: volatile oil consisted of 2.852%, isopropyl myristate 6.65%, polyoxyethylene hydrogenated castor oil 30.42%, absolute ethyl alcohol 7.605% and water 52.47%.
Conclusions:
Using pseudo-ternary phase diagram to optimize the formulation of Chinese herbs' micro-emulsion is scientific and feasible. The volatile oil's solubility is also increased by made of oil-in-water type micro-emulsion and insured the stability.
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