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[Cardiovascular biomarkers in clinical practice of sleep apnea]

Dursun Dursunoğlu1, Neşe Dursunoğlu

  • 1Department of Cardiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey. dursundursunoglu@yahoo.com

Tuberkuloz Ve Toraks
|January 12, 2012
PubMed

Insights

Obstructive sleep apnea syndrome (OSAS) significantly elevates cardiovascular risks, including heart failure and stroke. Reviewing cardiovascular biomarkers aids in early diagnosis and prognosis for OSAS patients.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Biomarker Research

Context:

  • Obstructive sleep apnea syndrome (OSAS) is linked to severe cardiovascular complications.
  • These complications include coronary artery disease, heart failure, hypertension, and stroke, increasing OSAS morbidity and mortality.
  • Heart failure patients may also experience sleep-related breathing disorders like Cheyne-Stokes respiration and various apneas.

Purpose:

  • To review the role of cardiovascular biomarkers in the early diagnosis, treatment, and prognosis of OSAS.
  • To explore the clinical significance of specific biomarkers in the context of OSAS-related cardiovascular pathology.

Summary:

  • OSAS contributes to a range of cardiovascular issues, including ventricular dysfunction, heart failure, and arrhythmias.
  • Hypoxemia-induced sympathetic overactivity and endothelial dysfunction are key mechanisms.
  • Key biomarkers discussed include C-reactive protein (CRP), TNF-α, interleukins, adiponectin, hFABP, and BNP.

Impact:

  • Highlights the importance of cardiovascular biomarkers for managing OSAS patients.
  • Provides insights into the pathophysiological links between sleep apnea and heart disease.
  • Aids clinicians in risk stratification and therapeutic decision-making for OSAS-related cardiovascular conditions.

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