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Related Experiment Videos

Transforming collaborations between ras and nuclear oncogenes.

H E Ruley1

  • 1Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.

Cancer Cells (Cold Spring Harbor, N.Y. : 1989)
|August 1, 1990
PubMed
Summary

Cellular oncogenes and DNA tumor viruses cooperate with ras oncogenes to induce cell transformation. These nuclear oncoproteins target proteins and nucleic acids, impacting transcription and cell cycle control for multistep carcinogenesis research.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Activated ras oncogenes can transform cells, but often require cooperation with other oncogenes.
  • Cellular oncogenes and DNA tumor viruses encode nuclear proteins that collaborate with ras.

Purpose of the Study:

  • To investigate the complementary interactions between oncogenes that enable ras-mediated cell transformation.
  • To understand the molecular mechanisms by which cooperating oncogenes facilitate transformation.

Main Methods:

  • Analysis of nuclear oncoproteins encoded by cellular oncogenes and DNA tumor viruses.
  • Studying the binding targets (protein and nucleic acid) of these oncoproteins.
  • Investigating effects on transcription and cell cycle control.

Main Results:

  • Nuclear oncoproteins from cellular oncogenes and DNA tumor viruses cooperate with activated ras oncogenes.
  • These collaborations release cells from inhibitory controls, enabling transformation.
  • Oncoproteins interact with protein and nucleic acid targets, influencing transcription and cell cycle.

Conclusions:

  • Cooperating oncogenes are essential for ras-mediated transformation of various cell types.
  • These interactions provide insights into normal growth control and multistep carcinogenesis.
  • Understanding these biochemical interactions is crucial for cancer research.

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