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Updated: May 25, 2026

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

Novel treatments for vasospasm after subarachnoid hemorrhage

Carl Muroi1, Martin Seule, Kenichi Mishima

  • 1Neurocritical Care Unit, University Hospital Zurich, Zurich, Switzerland.

Current Opinion in Critical Care
|January 12, 2012
PubMed

Insights

Treatment for cerebral vasospasm (CVS) after subarachnoid hemorrhage is evolving. Current evidence suggests CVS is not the only cause of poor outcomes, and novel treatments are under investigation.

Area of Science:

  • Neurocritical Care
  • Cerebrovascular Diseases
  • Neurosurgery

Background:

  • Cerebral vasospasm (CVS) following aneurysmal subarachnoid hemorrhage (aSAH) presents significant challenges in neurocritical care.
  • The understanding of delayed cerebral ischemia (DCI) and poor outcomes is expanding beyond CVS.

Purpose of the Study:

  • To review recent advancements and novel treatment strategies for CVS.
  • To discuss emerging factors contributing to DCI and poor outcomes after aSAH.

Main Methods:

  • Literature review of recent studies on CVS treatment.
  • Analysis of clinical trial results for novel therapeutic agents.

Main Results:

  • Treatment solely targeting CVS is considered outdated.
  • Early brain injury, cortical spreading depolarization, inflammation, and microthrombosis are implicated in DCI.
  • An endothelin-1 antagonist trial reduced CVS but did not improve outcomes.
  • Induced hypertension is recommended for DCI; endovascular intervention is for refractory CVS.
  • Magnesium sulfate and statins are in Phase III trials; other factors lack dedicated trials.

Conclusions:

  • Recent updates provide some revised recommendations for CVS management.
  • Novel treatment modalities are under investigation, but none have demonstrated convincing efficacy yet.
Abstract

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