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[Guidelines on the appropriate use of animal models for developing therapies in multiple sclerosis]
Beatriz Moreno1, Carmen Espejo, Leyre Mestre
1Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, España.
Introduction:
The advance in the achievement of effective therapies for multiple sclerosis (MS), the definition of appropriate therapeutic windows and to establish better diagnostic and prognostic biomarkers have become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might be related to lack of adequacy of the preclinical studies in MS experimental animal models.
Aim:
To standardize the methodological protocols of experimental models by developing a set of guidelines for preclinical studies by groups of experts from REEM (Spanish Network for MS).
Development:
A guide with recommendations for the application of MS models including a detailed assessment of appropriate experimental models taking into account the objective of the study that has been presented. Standards and quality criteria necessary in a preclinical study have been included.
Conclusions:
Standardized animal models of MS are essential to increase the success of the preclinical findings in order to transfer them to the clinical practice.
Insights
Standardizing experimental animal models for multiple sclerosis (MS) is crucial for improving preclinical study reliability. This ensures that research findings effectively translate to clinical practice and advance MS therapies.
Area of Science:
- Neuroscience
- Immunology
- Pharmacology
Context:
- Developing effective multiple sclerosis (MS) therapies and biomarkers presents significant challenges for researchers and clinicians.
- Preclinical studies using MS experimental animal models often lack methodological adequacy, potentially hindering clinical trial success.
Purpose:
- To standardize methodological protocols for experimental MS models.
- To develop expert-driven guidelines for preclinical MS research by the Spanish Network for MS (REEM).
Summary:
- This initiative provides a guide with recommendations for applying MS models, including assessing appropriate experimental models based on study objectives.
- The guide incorporates essential standards and quality criteria for preclinical MS studies.
Impact:
- Standardized MS animal models are vital for increasing the success rate of preclinical findings.
- Implementation of these guidelines aims to improve the translation of research discoveries into clinical practice for multiple sclerosis treatment.
