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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Increasing physical activity in multiple sclerosis: replicating Internet intervention effects using objective and

Deirdre Dlugonski1, Robert W Motl, Edward McAuley

  • 1Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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An Internet intervention effectively increased physical activity in individuals with multiple sclerosis (MS), confirmed by objective accelerometer data and self-report questionnaires. Higher engagement with the intervention correlated with greater objective increases in physical activity.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Digital Health

Background:

  • Previous research demonstrated an Internet intervention's effectiveness for self-reported physical activity in multiple sclerosis (MS).
  • Objective measures were needed to validate the intervention's impact on physical activity in this population.

Purpose of the Study:

  • To evaluate the efficacy of an Internet intervention for increasing physical activity in persons with MS.
  • To compare objective (accelerometer) and self-report (IPAQ, GLTEQ) measures of physical activity changes.

Main Methods:

  • Twenty-one participants with MS underwent a 12-week Internet intervention.
  • Objective physical activity was measured using waist-worn accelerometers for 7 days.
  • Self-reported physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) and Godin Leisure-Time Exercise Questionnaire (GLTEQ) pre- and post-intervention.

Main Results:

  • The intervention led to moderate increases in accelerometer activity counts (d = 0.68) and step counts (d = 0.60).
  • Small increases were observed in IPAQ (d = 0.43) and GLTEQ (d = 0.34) scores.
  • Intervention adherence (weeks logged on) positively correlated with changes in accelerometer (r = 0.42) and step counts (r = 0.37), but not self-report scores.

Conclusions:

  • The Internet intervention is efficacious in increasing physical activity in persons with MS, supported by both objective and self-report data.
  • Objective measures provide stronger evidence of the intervention's impact compared to self-report measures.
  • Adherence to the online platform is crucial for maximizing objective physical activity gains.