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Related Experiment Video

Updated: May 25, 2026

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
10:41

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

Published on: June 3, 2021

Acute perfusion changes after spontaneous SAH: a perfusion CT study.

Alfonso Lagares1, Marta Cicuendez, Ana Ramos

  • 1Department of Neurosurgery, Hospital 12 de Octubre, Crta de Andalucia km 5.4, Madrid, Spain. algadoc@yahoo.com

Acta Neurochirurgica
|January 12, 2012
PubMed
Summary

Perfusion CT reveals increased circulation times (TTP and MTT) in subarachnoid hemorrhage (SAH) patients, correlating with bleeding severity and predicting poor outcomes and delayed cerebral ischemia.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Perfusion computed tomography (CT) measures cerebral blood flow disturbances in stroke and subarachnoid hemorrhage (SAH).
  • Acute SAH requires rapid assessment of cerebral perfusion to understand its impact.

Purpose of the Study:

  • To correlate perfusion CT measures with SAH severity and patient outcomes.
  • To establish the relationship between dynamic-contrast CT perfusion data and clinical grading, bleeding extent, and patient prognosis.

Main Methods:

  • Perfusion CT was performed after conventional CT diagnosis of SAH.
  • Quantitative perfusion parameters (MTT, TTP, CBV, CBF) were analyzed using specialized software.
  • Clinical data, including consciousness level, bleeding volume, ICP, delayed cerebral ischemia (DCI), and Glasgow Outcome Scale, were collected.

Related Experiment Videos

Last Updated: May 25, 2026

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
10:41

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

Published on: June 3, 2021

Main Results:

  • Perfusion abnormalities, particularly increased TTP and MTT, significantly correlated with SAH severity (P < 0.01).
  • An average MTT > 5.9s indicated a 20-fold increased risk of poor outcome and was 100% predictive of DCI.
  • This MTT threshold demonstrated 90% positive predictive value for poor outcomes.

Conclusions:

  • SAH acutely causes cerebral blood flow abnormalities, primarily increased circulation times (TTP and MTT).
  • These circulation time increases are directly correlated with the severity of the subarachnoid hemorrhage.