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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...

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Updated: May 25, 2026

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

Midkine in inflammation.

Ludwig T Weckbach1, Takashi Muramatsu, Barbara Walzog

  • 1Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, 80336 Munich, Germany.

Thescientificworldjournal
|January 12, 2012
PubMed
Summary
This summary is machine-generated.

Midkine (MK), a heparin-binding growth factor, plays a key role in inflammation. Its absence alleviates inflammatory diseases by reducing leukocyte recruitment and modulating immune responses.

Keywords:
Leukocytescytokinesimmunity.

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A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

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Published on: December 9, 2021

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

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Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators
08:54

Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators

Published on: December 1, 2008

Area of Science:

  • Immunology
  • Developmental Biology
  • Molecular Biology

Background:

  • Midkine (MK) is a heparin-binding growth factor initially identified for its role in embryonic development.
  • Emerging research highlights MK's involvement in both acute and chronic inflammatory processes.
  • Studies indicate that inflammatory conditions such as nephritis, arthritis, and colitis are ameliorated in MK-deficient animal models.

Purpose of the Study:

  • To review the current understanding of midkine's role in various inflammatory disorders.
  • To summarize the known biology of midkine in the context of inflammation.

Main Methods:

  • Review of existing literature on midkine and inflammatory diseases.
  • Analysis of mechanisms underlying midkine's influence on inflammation.

Main Results:

  • Absence of MK attenuates chronic inflammation, notably by reducing leukocyte recruitment to inflammatory sites.
  • MK influences the expression of pro-inflammatory cytokines.
  • MK modulates the expansion of regulatory T-cells, impacting immune homeostasis.

Conclusions:

  • Midkine is a significant mediator of inflammatory processes.
  • Targeting midkine may offer therapeutic potential for inflammatory and autoimmune diseases.