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In vitro study of neuroprotective properties of GK-2, a new original nerve growth factor mimetic
T A Antipova1, T A Gudasheva, S B Seredenin
1V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. niipharm@mail.ru
Abstract:
New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10(-9)M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H(2)O(2)and glutamate. GK-2 in a concentration of 10(-8)M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.
