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Classification of functional dyspepsia based on concomitant bowel symptoms.
J Matsuzaki1, H Suzuki, K Asakura
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Neurogastroenterology and Motility
|January 13, 2012
Summary
Functional dyspepsia (FD) symptom severity is linked to bowel issues, particularly in postprandial distress syndrome (PDS). This new FD classification may enhance patient grouping.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Digestive Health
Background:
- Functional dyspepsia (FD) is a complex condition with overlapping postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) symptoms.
- Current categorization of FD may not fully capture patient heterogeneity.
Purpose of the Study:
- To investigate if FD can be sub-categorized based on the presence of concurrent gastrointestinal symptoms.
- To explore the relationship between bowel symptoms and FD severity.
Main Methods:
- A large-scale web survey collected data on gastrointestinal symptoms (GSRS), Rome III criteria for FD, and demographics.
- Factor and cluster analyses were employed to identify FD sub-categories.
Main Results:
- Out of 8038 participants, 563 met FD criteria. Cluster analysis identified constipation-predominant (C), diarrhea-predominant (D), and neither (nCnD) bowel symptom groups.
- Both cluster C and D showed a significant association with FD.
- FD patients, especially those with PDS, exhibited higher upper gastrointestinal symptom scores in clusters C and D compared to nCnD.
Conclusions:
- Dyspepsia symptom severity correlates with the presence of bowel symptoms, particularly in PDS.
- A novel FD classification incorporating concomitant constipation or diarrhea could refine patient categorization and management.
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