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Bone marrow microenvironment: a newly recognized target for diabetes-induced cellular damage

Giuseppe Mangialardi1, Atsuhiko Oikawa, Carlotta Reni

  • 1Chair of Experimental Cardiovascular Medicine, Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK.

Endocrine, Metabolic & Immune Disorders Drug Targets
|January 13, 2012
PubMed

Insights

Diabetes impairs bone marrow progenitor cells crucial for tissue repair, leading to worse cardiovascular outcomes. This review details diabetes-induced damage to these cells in their niches.

Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Hematology

Background:

  • Diabetes mellitus is strongly linked to cardiovascular morbidity and mortality.
  • Diabetic patients experience more frequent and severe cardiovascular events.
  • Impaired cellular regeneration contributes to poorer tissue healing in diabetes.

Purpose of the Study:

  • To review evidence on diabetes-induced damage to bone marrow progenitor cells.
  • To explore the impact of diabetes on cell mobilization, recruitment, and function.
  • To highlight damage within endosteal and vascular niches of bone marrow.

Main Methods:

  • Literature review of current evidence.
  • Analysis of studies on progenitor cell function in diabetes.
  • Examination of bone marrow niches (endosteal and vascular).

Main Results:

  • Diabetes negatively affects the mobilization and recruitment of bone marrow-derived progenitor cells.
  • Intrinsic functional properties of these progenitor cells are impaired by diabetes.
  • Evidence points to diabetes-induced damage in both endosteal and vascular bone marrow niches.

Conclusions:

  • Diabetes compromises the regenerative capacity by damaging bone marrow progenitor cells.
  • This damage contributes to the increased cardiovascular complications observed in diabetic patients.
  • Understanding these mechanisms is vital for improving therapeutic strategies in diabetes.

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