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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Updated: May 25, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
04:35

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

Radiotherapy-induced myelosuppression in dogs: 103 cases (2002-2006).

T Clermont1, A K Leblanc, W H Adams

  • 1Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, TN37996, USA.

Veterinary and Comparative Oncology
|January 13, 2012
PubMed
Summary
This summary is machine-generated.

Definitive radiotherapy in dogs caused temporary reductions in blood cell counts, but these remained within normal ranges. Routine blood monitoring is not recommended during this cancer treatment.

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Published on: October 24, 2016

Area of Science:

  • Veterinary Oncology
  • Radiation Oncology
  • Hematology

Background:

  • Definitive radiotherapy is a common cancer treatment in dogs, involving high doses of radiation over several weeks.
  • The effects of definitive radiotherapy alone on canine hematopoiesis (blood cell production) are not well understood.

Purpose of the Study:

  • To evaluate the impact of definitive radiotherapy on complete blood count parameters in tumor-bearing dogs.
  • To determine if routine hematological monitoring is necessary during definitive radiotherapy in dogs.

Main Methods:

  • A retrospective review of 103 dogs receiving definitive (60) Cobalt teletherapy for cancer.
  • Collection and analysis of complete blood count data before, during, and after radiation treatment.
  • Analysis of changes in hematological parameters in relation to patient variables.

Main Results:

  • Significant reductions were observed in hematocrit, white blood cells, neutrophils, eosinophils, monocytes, lymphocytes, and platelets during radiotherapy.
  • All measured hematological parameters remained within established laboratory reference intervals throughout treatment.
  • No correlation was found between patient variables and hematological changes.

Conclusions:

  • Definitive radiotherapy alone causes transient, non-clinically significant decreases in blood cell counts in dogs.
  • These findings are valuable for predicting potential toxicities when combining radiotherapy with chemotherapy.
  • Routine hematological monitoring is not supported during definitive radiotherapy in dogs.