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Related Concept Videos

Oral Cavity01:11

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

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Related Experiment Video

Updated: May 25, 2026

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry
08:37

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Published on: August 7, 2012

Peptides in oral diseases.

Alberta Lucchese1, Agostino Guida, Massimo Petruzzi

  • 1Department of Odontostomatological, Orthodontics and Surgical Disciplines, Second University of Naples SUN, Via De Crecchio 6, Naples, Italy. alberta.lucchese@unina2.it

Current Pharmaceutical Design
|January 13, 2012
PubMed
Summary

Antimicrobial peptides offer promising targeted therapies for diverse oral diseases caused by microbial infections. This review explores their potential in treating conditions from tooth decay to oral cancers.

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Last Updated: May 25, 2026

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry
08:37

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Published on: August 7, 2012

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
08:41

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro

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Area of Science:

  • Oral microbiology and immunology
  • Infectious diseases
  • Peptide therapeutics

Background:

  • The oral cavity harbors diverse microbes implicated in various oral and systemic diseases.
  • Microbial infections are central to oral conditions like tooth decay, periodontal disease, candidiasis, and oral cancers.
  • Targeted therapies are crucial for managing oral infections in this complex environment.

Purpose of the Study:

  • To review the therapeutic potential of antimicrobial peptides in oral and dental research.
  • To highlight peptides targeting infectious agents and modulating host responses in oral diseases.

Main Methods:

  • Literature review of antimicrobial peptides and their roles in oral diseases.
  • Analysis of peptides including LL-37, beta defensins, adrenomedullin, and histatins.
  • Examination of peptides influencing gene expression and immune interactions.

Main Results:

  • Antimicrobial peptides show promise for targeted treatment of oral infections.
  • Specific peptides like LL-37 and beta defensins possess broad-spectrum antimicrobial activity.
  • Other peptides modulate host gene expression and immune responses relevant to oral health.

Conclusions:

  • Peptide-based therapies represent a significant area of interest for oral and dental research.
  • Targeted peptide approaches can effectively combat microbial agents in the oral cavity.
  • Further research into peptide therapeutics can lead to novel treatments for a range of oral disorders.