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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

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Published on: November 10, 2013

Next-generation anticancer metallodrugs.

Seiji Komeda1, Angela Casini

  • 1Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan. komedas@suzukau. ac.jp

Current Topics in Medicinal Chemistry
|January 13, 2012
PubMed
Summary
This summary is machine-generated.

Metallodrugs, particularly platinum-based compounds, are vital in cancer chemotherapy. Research is expanding to explore other metal-based drugs, like gold and ruthenium complexes, for enhanced anticancer therapies.

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Area of Science:

  • Inorganic biochemistry
  • Medicinal chemistry
  • Cancer research

Background:

  • Most approved drugs are organic; metallodrugs are rare but clinically significant.
  • Platinum-based drugs (e.g., cisplatin) are essential anticancer agents.
  • The success of platinum drugs fuels research into novel metallodrugs.

Purpose of the Study:

  • To review the potential of metallodrugs in cancer therapy.
  • To discuss recent advancements in platinum-, ruthenium-, and gold-based anticancer compounds.
  • To explore their mechanisms of action and molecular targets.

Main Methods:

  • Literature review of inorganic biochemistry and medicinal chemistry research.
  • Analysis of recent families of platinum (Pt), ruthenium (Ru), and gold (Au) coordination complexes.
  • Discussion of proposed modes of action and biomolecular targets.

Main Results:

  • Platinum compounds remain crucial in cancer treatment.
  • Gold complexes show significant cytotoxic properties.
  • Ruthenium complexes demonstrate potential in inhibiting tumor metastasis.

Conclusions:

  • Metallodrugs offer a promising avenue for cancer therapy.
  • Further research into Pt, Ru, and Au complexes may yield improved anticancer agents.
  • Understanding mechanisms and targets is key to developing effective metallodrugs.