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Related Experiment Video

Updated: May 25, 2026

Intravital Video Microscopy Measurements of Retinal Blood Flow in Mice

Intravital Video Microscopy Measurements of Retinal Blood Flow in Mice

Published on: December 26, 2013

Decreased blood pressure with a corresponding decrease in adhesive molecules in diabetic rats caused by vitamin E

Alireza Shirpoor¹, Mohammad-Hasan Khadem Ansari, Behnam Heshmatian

¹Department of Physiology, Faculty of Medicine, Urmia Medical University, Urmia, Iran. ashirpoor@yahoo.com

Journal of Diabetes

|January 13, 2012

Summary

Vitamin E supplementation significantly improved blood pressure and reduced inflammatory markers in diabetic rats, suggesting a potential therapeutic role for vitamin E in managing diabetic cardiovascular complications.

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Area of Science:

Cardiovascular Science
Endocrinology
Nutritional Science

Background:

Hypertension is a critical complication of diabetic cardiovascular disease.
Diabetic rats exhibit elevated blood pressure and inflammatory markers.

Purpose of the Study:

To investigate the effect of vitamin E on blood pressure and adhesion molecules in diabetic rats.
To explore vitamin E's potential in mitigating diabetic cardiovascular complications.

Main Methods:

Twenty-four Wistar rats were divided into control, diabetic, and vitamin E-treated diabetic groups.
Diabetes was induced using streptozotocin; vitamin E was administered orally for six weeks.
Blood pressure parameters and plasma levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin were measured.

Main Results:

Diabetic rats showed significantly increased systolic/diastolic blood pressure, mean arterial pressure, and adhesion molecules (ICAM-1, E-selectin).
Vitamin E treatment led to significant improvements in blood pressure and reduced levels of ICAM-1 and E-selectin.
No significant differences were observed in heart rate or cardiac cyclic duration.

Conclusions:

Vitamin E effectively improved blood pressure in diabetic rats.
The beneficial effects of vitamin E may be linked to its antioxidant properties and reduction of inflammatory adhesion molecules.