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Related Experiment Video

Updated: May 25, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

Enteric alpha defensins in norm and pathology.

Nikolai A Lisitsyn¹, Yulia A Bukurova, Inna G Nikitina

¹Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St,, Moscow, Russian Federation. niklisitsyn@yahoo.com

Annals of Clinical Microbiology and Antimicrobials

|January 13, 2012

Summary

Enteric alpha defensins are key regulators of gut microbes and immune responses. Their altered secretion is linked to intestinal inflammation and cancer, highlighting their role in gut health.

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Last Updated: May 25, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

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Published on: December 3, 2020

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model

Published on: February 11, 2021

Area of Science:

Microbiology
Immunology
Gastroenterology

Background:

Mammalian gut microbes interact constantly with the host immune system.
Enteric alpha defensins are crucial for controlling gut bacterial colonization.
These defensins also modulate adaptive immune cell responses in the gut lining.

Purpose of the Study:

To review the functions of mammalian enteric alpha defensins in immune defense.
To examine changes in enteric alpha defensin secretion during intestinal diseases.

Main Methods:

Literature review of existing studies on enteric alpha defensins.
Analysis of data on immune defense mechanisms.
Examination of secretion patterns in inflammatory conditions and cancer.

Main Results:

Enteric alpha defensins regulate bacterial populations in the gut.
They influence both pro- and anti-inflammatory immune responses.
Secretion levels are altered in intestinal inflammatory diseases and cancer.

Conclusions:

Enteric alpha defensins are vital components of gut immune homeostasis.
Dysregulation of these peptides is associated with gastrointestinal pathologies.
Further research into enteric alpha defensins may offer therapeutic insights.