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Published on: July 21, 2018
Leptin, MUC2 and mTOR in appendiceal mucinous neoplasms
Mee Soo Chang1, Sun-ju Byeon, Sun Och Yoon
1Department of Pathology, Seoul National University Boramae Hospital, Seoul, Korea. meesooch@snu.ac.kr
Summary
Leptin, MUC2, and MUC5AC proteins are involved in appendiceal mucinous neoplasms. MUC2 and mTOR show potential as molecular therapy targets for these cancers.
Area of Science:
- Gastroenterology
- Oncology
- Molecular Biology
Background:
- Leptin influences mucin production and carcinogenesis in the colon.
- Understanding proteins in mucin-producing appendiceal neoplasms is crucial for targeted therapy.
Purpose of the Study:
- To investigate proteins in appendiceal mucinous neoplasms.
- To identify potential molecular therapy targets for these tumors.
Main Methods:
- Immunohistochemistry and fluorescence in situ hybridization were used.
- Analyzed 22 adenomas, 20 neoplasms of uncertain malignant potential, and 14 adenocarcinomas.
Main Results:
- Leptin, MUC2, MUC5AC, mTOR, and ERK were elevated in adenocarcinomas.
- STAT3 was immunopositive in 82% of tumors; MUC2 correlated with pseudomyxoma peritonei.
- mTOR positivity was linked to poorer disease-free survival.
Conclusions:
- Leptin may interact with MUC2 and MUC5AC via mTOR, STAT3, and ERK pathways.
- STAT3 activation may occur early in tumorigenesis.
- MUC2 and mTOR are potential therapeutic targets for appendiceal mucinous adenocarcinoma and pseudomyxoma peritonei.
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