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[The mechanisms of persistent measles virus infection in HEp-2 cells]

C Cernescu1, M Iftimovici, D Rojanski

  • 1Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.

Revue Roumaine De Virologie (Bucharest, Romania : 1990)
|January 1, 1990
PubMed

Insights

Persistent measles virus infection in HEp-2 cells showed altered virus characteristics and reduced cell fusion. Reactivation of the lytic cycle has potential clinical implications for measles virus carriers.

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Context:

  • Persistent measles virus infection established in HEp-2 cells.
  • Characterization of morphological and cytogenic aspects of this persistent infection.

Purpose:

  • To investigate the characteristics of measles virus during persistent infection.
  • To explore factors influencing the cytocidal effect and lytic cycle reactivation.

Summary:

  • Persistent measles virus (Edmonston strain) infection in HEp-2 cells resulted in altered virus stocks with decreased cell fusion capacity and lower infectious virus yield.
  • Factors such as UV-inactivated Sendai virus, trypsin treatment, or suboptimal temperatures can trigger the cytocidal effect of measles virus in persistently infected cells.

Impact:

  • Highlights differences between standard and carrier-state measles virus strains.
  • Suggests clinical implications of measles virus lytic cycle reactivation in carrier states.
  • Provides insights into measles virus persistence and host-cell interactions.

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