Related Experiment Video

Updated: May 25, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Efficacious treatment of non-dermatophyte mould onychomycosis with topical amphotericin B

Massimo Lurati1, Florence Baudraz-Rosselet, Maxime Vernez

  • 1Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Dermatology (Basel, Switzerland)
|January 13, 2012
PubMed
Abstract

Insights

Topical amphotericin B effectively treated non-dermatophyte mould (NDM) onychomycosis in patients resistant to standard therapies. This safe and affordable treatment offers a promising solution for difficult-to-treat nail infections.

Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Non-dermatophyte moulds (NDMs) are increasingly implicated in onychomycosis, particularly in nails with existing abnormalities.
  • Many NDMs, including Fusarium spp., exhibit resistance to conventional topical and systemic antifungal treatments like terbinafine and itraconazole.
  • This resistance poses a significant challenge for effective onychomycosis management.

Observation:

  • This study evaluated the efficacy of a novel topical amphotericin B solution for treating NDM onychomycosis.
  • Eight patients with treatment-resistant NDM onychomycosis participated in the study.
  • The treatment involved daily application of the optimized amphotericin B solution to affected nails and surrounding skin.

Findings:

  • Clinical cure of onychomycosis was achieved in all 8 patients after a 12-month treatment period.
  • Mycological cure was observed in 7 out of 8 patients.
  • The topical amphotericin B treatment demonstrated high efficacy in resolving NDM onychomycosis.

Implications:

  • Topical amphotericin B presents a safe, cost-effective, and user-friendly therapeutic option for NDM onychomycosis.
  • This treatment should be strongly considered for NDM onychomycosis, especially in cases resistant to standard therapies.
  • Further research may establish topical amphotericin B as a first-line treatment for NDM onychomycosis.

More Related Videos

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...